20th MEET THE PROFESSOR

Advanced International Breast Cancer Course

Padova | October 24-25, 2024
Centro Culturale S. Gaetano Altinate

Presentation

Aims

Breast cancer research has been the frontrunner in many fields of cancer research: epidemiology, life-style and genetic risk factors, secondary prevention, conservative surgery, molecular classification, curative adjuvant therapies, neoadjuvant treatments, targeted agents, survival prolongation in advanced stages. Thanks to this knowledge, today many breast cancers can be prevented, most can be diagnosed at early stages and cured and the minority of patients at advanced stages can still enjoy a significant survival with a reasonable quality of life.

As a consequence of these major improvements, the bar of research and clinical excellence for breast cancer has raised even more.

New prognostic and predictive biomarkers are available, need to be validated and to be implemented in trial design and clinical practice. Risk-adapted surgery and radiation therapy allow for less and less invasive procedures. Multiple effective adjuvant therapies in the different molecular breast cancer subtypes, require a more precise definition of risk and predictivity of drug efficacy, to allow for a rational de-escalation or escalation of curative treatments. The impressive advances in the treatment of advanced breast cancers, envisage the possibility of cure with a multimodality approach for some patients and guarantee a prolonged survival for most of them with a rational sequencing of treatments.

The 20th AIBCC in Padova, will allow to sum up the most recent biological and clinical achievements and to allow an open and friendly discussion of clinical cases among key opinion leaders and participants.

Addressed to

  • Gynecologists and obstetrics

  • Medical oncologists

  • Pathologists

  • Radiologists

  • Radiation oncologists

  • Surgeons

  • Biologists

  • Pharmacists

  • Nurses

Scientific Program

Thursday, October 24th

10:30 Introduction to the Conference
Pierfranco Conte, Valentina Guarneri, Philip Poortmans, Aleix Prat
SESSION I – EVOLVING KNOWLEDGE OF BREAST CANCER BIOLOGY: IMPLICATIONS FOR STAGING, PROGNOSIS AND PREDICTION

Chairpersons: Maria Vittoria Dieci, Hesham Ahmed Gaballah Elghazaly

11.00 Gene expression tools in early-stage HR+/HER2- breast cancer: questioning the grey areas
Alberto Zambelli
11.20 The immune system and breast cancer: TNBC and beyond
Marleen Kok
11.40 DNA NGS-based biomarkers to inform treatment sequence in advanced breast cancer
Mafalda Oliveira
12.00 Tackling the biological diversity in HER2-positive breast cancer: clinical implications
Aleix Prat
12.20 Discussion
12.50 Lunch
SESSION II – LOCOREGIONAL Tx AND GENOMICS

Chairpersons: Eleftherios Mamounas, Jacek Jassem

14.00 Surgery of the axilla: is less always more?
Oreste Davide Gentilini
14.20 Navigating RT options according to genetic risck profiles
Philip Poortmans
14.40 Evolving concepts in genetic testing: finding the balance
Angela Toss
15.00 Discussion
SESSION III – EARLY BREAST CANCER: NEOADJUVANT AND POST-NEOADJUVANT THERAPY

Chairpersons: Pierfranco Conte, Sibylle Loibl

15.30 Modulation of neoadjuvant and post-neoadjuvant treatment in HER2+ (pert, TDM1, neratinib,trials)
Sibylle Loibl
15.50 Modulation of neoadjuvant and post-neoadjuvant treatment in TNBC (IO, PARPi, capecitabine)
Pierfranco Conte
16.10 Indication to and modalities of neoadjuvant Tx in HR+HER2- BC
Valentina Guarneri
16.30 Discussion
17.00 Adjourn
17.15 Ceremony for the presentation of the University of Padua Award for Advances in Breast Cancer 2024
17.30 Lecture of the Awardee
18.00 Adjourn

Friday, October 25th

SESSION IV – EARLY BREAST CANCER

Chairpersons: Valentina Guarneri, Aleix Prat

9.00 Enhancing efficacy of hormonal therapy in early breast cancer (bisphosphonates, extended, CDK4/6i, SERDs, PARPi…)
Stephen Johnston
9.20 Optimizing treatment for small tumors depending on local treatments
Hope Rugo
9.40 The challenge of lobular breast cancer
Maria Vittoria Dieci
10.00 Discussion
10.30 Coffee break
11.00 Clinical Multidisciplinary Shooting Session 1 – Early Breast Cancer
Panelist: Bettina Borisch, Hesham Ahmed Gaballah Elghazaly, Oreste Davide Gentilini, Jacek Jassem, Sibylle Loibl, Eleftherios Mamounas, Alberto Marchet, Fedro Alessandro Peccatori, Philip Poortmans, Aleix Prat
12.30 Lunch
SESSION V METASTATIC BREAST CANCER: CONSOLIDATED AND NEW ALGORITHMS

Chairpersons: Pierfranco Conte, Sandra Swain M

13.30 HR+ disease
Current algorithm: Claudio Vernieri
Adapting the algorithm in a contemporary scenario: Carmen Criscitiello
14.00 HER2+ disease
Current algorithm: Federica Miglietta
Treatment sequences in new emerging populations: Sandra Swain
14.30 Triple negative disease
Current algorithm: Gaia Griguolo
Treatment sequences in new emerging populations: Hope Rugo
15.00 Discussion
15.20 Clinical Multidisciplinary Shooting Session 2 – Advanced Breast Cancer
Panelist: Pierfranco Conte, Hesham Ahmed Gaballah Elghazaly, Oreste Davide Gentilini, Stephen Johnston, Philip Poortmans, Hope Rugo, Sandra Swain M
16.40 Take home messages and adjourn
Pierfranco Conte, Valentina Guarneri, Philip Poortmans, Aleix Prat

Faculty

Honorary President

Gabriel N. Hortobagyi
Gabriel N. HortobagyiHouston (US)
Department of Breast Medical Oncology
The University of Texas – MD Anderson Cancer Center

Directors

Pierfranco Conte
Pierfranco ConteVenezia (IT)
Coordinator Molecular Tumor Board, Rete Oncologica Veneta, Padova (IT)
Scientific Director S. Camillo Hospital, IRCCS, Venezia (IT)
Valentina Guarneri
Valentina GuarneriPadova (IT)
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
Department of Surgery, Oncology and Gastroenterology
Philip Poortmans
Philip PoortmansWilrijk-Antwerp (BE)
Former president of ESTRO and of ECCO
Department of Radiation Oncology
Iridium Netwerk
University of Antwerp (BE)
Aleix Prat
Aleix PratBarcellona (ES)
Director Clínic’s Institute of Hematological and Oncological Diseases (ICMHO)
University Barcellona (ES)

Scientific Committee

Bettina Borisch
Geneve (CH)

Maria Vittoria Dieci
Padova (IT)

Hesham Ahmed Gaballah Elghazaly
Cairo (EG)

Jacek Jassem
Gdansk (PL)

Stephen Johnston
London (UK)

Sibylle Loibl
Frankfurt (DE)

Eleftherios Mamounas
Orlando (US)

Fedro Alessandro Peccatori
Milano (IT)

Sandra M. Swain
Washington (US)

Speakers

Carmen Criscitiello
Milano (IT)

Oreste Davide Gentilini
Milano (IT)

Gaia Griguolo
Padova (IT)

Marleen Kok
Amsterdam (NL)

Alberto Marchet
Padova (IT)

Federica Miglietta
Padova (IT)

Mafalda Oliveira
Barcellona (ES)

Hope Rugo
San Francisco (USA)

Angela Toss
Modena (IT)

Claudio Vernieri
Milano (IT)

Alberto Zambelli
Milano (IT)

Download all the slides of AIBCC 2023.

With the patronage of

INSTITUTIONS

SCIENTIFIC SOCIETIES